Rogerio Augusto Pinto da Silva, MD
Belo Horizonte, Minas Gerais State – Brazil
Email: ecosala1@gmail.com
Clinical History:
A 94-days-old boy referred to ultrasound imaging due to the development of jaundice.
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| CORRECT ANSWER EXPLAINED BELOW | |
ExplanationBiliary atresia can be diagnosed based on biliary hilar thickening (the so called triangular cord sign), hypoplastic gallbladder, and enlarged hepatic artery – the relation between it and the right hepatic portal branch is = 0.66 (Normal < 0.50). Except for the periportal thickening, the liver keeps its usual sonographic features. Indirect signs of liver disease as ascites and splenomegaly are the only suspicious findings on B-mode ultrasound. Elastography, specially 2D-SWE, has an important role as it can show increased liver stiffness, usually above 20 kPa. This is due to biliary atresia as well as to liver cirrhosis that is already present at this age. The child was referred to liver transplantation. Expected findings related to the alternative answers Answer 1: Neonatal hepatitis – Liver has normal sonographic features. Liver stiffness can be slightly increased, around 10 to 15 kPa. Answer 2: Obstruction due to biliary sludge – in this setting there is biliary dilation. The sludge can be seen inside the common bile duct. Answer 3: Congenital cirrhosis – due to multiple causes, as congenital infections, metabolic disorders, gestational alloimmune liver disease, haemophagocytic lymphohistiocytosis, and ischaemic injury. If cirrhosis develops during pregnancy, the newborn shows signs of liver failure. Portal hypertension signals can be depicted by Doppler. In this setting the ductus venosus does not close, and can be seen with flow at color Doppler. Usually, the liver has no other suspicious findings References
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| CORRECT ANSWER EXPLAINED BELOW | |
ExplanationBiliary atresia can be diagnosed based on biliary hilar thickening (the so called triangular cord sign), hypoplastic gallbladder, and enlarged hepatic artery – the relation between it and the right hepatic portal branch is = 0.66 (Normal < 0.50). Except for the periportal thickening, the liver keeps its usual sonographic features. Indirect signs of liver disease as ascites and splenomegaly are the only suspicious findings on B-mode ultrasound. Elastography, specially 2D-SWE, has an important role as it can show increased liver stiffness, usually above 20 kPa. This is due to biliary atresia as well as to liver cirrhosis that is already present at this age. The child was referred to liver transplantation. Expected findings related to the alternative answers Answer 1: Neonatal hepatitis – Liver has normal sonographic features. Liver stiffness can be slightly increased, around 10 to 15 kPa. Answer 2: Obstruction due to biliary sludge – in this setting there is biliary dilation. The sludge can be seen inside the common bile duct. Answer 3: Congenital cirrhosis – due to multiple causes, as congenital infections, metabolic disorders, gestational alloimmune liver disease, haemophagocytic lymphohistiocytosis, and ischaemic injury. If cirrhosis develops during pregnancy, the newborn shows signs of liver failure. Portal hypertension signals can be depicted by Doppler. In this setting the ductus venosus does not close, and can be seen with flow at color Doppler. Usually, the liver has no other suspicious findings References
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